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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAD1L1
All Species:
30
Human Site:
Y649
Identified Species:
66
UniProt:
Q9Y6D9
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6D9
NP_001013858.1
718
83067
Y649
D
I
T
T
E
N
Q
Y
R
L
T
S
L
Y
A
Chimpanzee
Pan troglodytes
XP_518933
718
83078
Y649
D
I
T
T
E
N
Q
Y
R
L
T
S
L
Y
A
Rhesus Macaque
Macaca mulatta
XP_001102100
956
108383
Y649
D
I
T
T
E
N
Q
Y
R
L
T
S
L
Y
A
Dog
Lupus familis
XP_852066
833
95008
Y764
D
I
T
T
E
N
Q
Y
R
L
T
S
M
Y
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9WTX8
717
83523
Y648
D
V
T
T
E
S
Q
Y
R
L
T
S
R
Y
A
Rat
Rattus norvegicus
NP_001102857
717
83311
Y648
D
V
T
T
E
S
Q
Y
R
L
T
S
R
Y
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_425231
717
83910
Y648
D
I
T
T
E
N
Q
Y
R
L
T
S
I
Y
A
Frog
Xenopus laevis
P10999
583
67273
W515
S
P
P
T
D
L
V
W
K
S
Q
K
T
W
G
Zebra Danio
Brachydanio rerio
NP_957206
323
37683
L255
T
V
E
N
Q
Y
R
L
T
S
V
Y
A
E
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796080
709
81997
Y641
N
N
P
T
T
N
Q
Y
K
L
L
S
M
Y
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001151757
716
81232
R647
S
N
G
I
P
V
T
R
F
I
L
Q
S
V
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
73.1
72.3
N.A.
81
83
N.A.
N.A.
69.9
20.6
27.9
N.A.
N.A.
N.A.
N.A.
33.1
Protein Similarity:
100
99.5
73.8
80.1
N.A.
90.8
92.1
N.A.
N.A.
84.6
40.5
37.7
N.A.
N.A.
N.A.
N.A.
59.3
P-Site Identity:
100
100
100
93.3
N.A.
80
80
N.A.
N.A.
93.3
6.6
0
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
100
33.3
20
N.A.
N.A.
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
23.2
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
46.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
73
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
64
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
10
0
64
0
0
0
0
0
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% F
% Gly:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
46
0
10
0
0
0
0
0
10
0
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
19
0
0
10
0
0
0
% K
% Leu:
0
0
0
0
0
10
0
10
0
73
19
0
28
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
19
0
0
% M
% Asn:
10
19
0
10
0
55
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
19
0
10
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
73
0
0
0
10
10
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
10
64
0
0
0
19
0
0
% R
% Ser:
19
0
0
0
0
19
0
0
0
19
0
73
10
0
0
% S
% Thr:
10
0
64
82
10
0
10
0
10
0
64
0
10
0
0
% T
% Val:
0
28
0
0
0
10
10
0
0
0
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
10
0
0
0
0
0
10
0
% W
% Tyr:
0
0
0
0
0
10
0
73
0
0
0
10
0
73
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _